{"created":"2025-06-04T07:07:12.411456+00:00","id":2000061,"links":{},"metadata":{"_buckets":{"deposit":"87f926a9-9f51-4f02-b687-225fb7921b8b"},"_deposit":{"created_by":7,"id":"2000061","owner":"7","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2000061"},"status":"published"},"_oai":{"id":"oai:bpur.repo.nii.ac.jp:02000061","sets":["1721794136137:1721794263913"]},"author_link":["10","28","29","11"],"item_10002_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicNumberOfPages":"12","bibliographicPageEnd":"40","bibliographicPageStart":"29","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"びわこ健康科学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Biwako Journal of Rehabilitation","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Protein kinase C（PKC）ファミリーは，アルツハイマー病（AD）のタウ病理に関連することが知られて\nいる．Novel PKC アイソフォームの一つであるPKC delta（PKCδ）は，ヒトの脳において細胞特異的で\nはなく普遍的な役割を果たしており，成長，分化，アポトーシスの制御などの細胞機能において重要で\nある可能性がある．しかし，AD脳におけるPKCδの局在と機能に関する情報が殆どない．本研究では，\n免疫組織化学法を用いて，高齢健常者およびAD患者の剖検脳におけるPKCδの局在を検索した．高齢\n健常脳では海馬の顆粒層において，PKCδの点状染色が錐体細胞の細胞質または核で観察された．一方，\nAD脳では，錐体ニューロン細胞体におけるPKCδの発現は高齢健常脳よりも低かった．さらに，AD海\n馬の老人斑内，多数の神経原線維変化（NFT）および変性神経突起は，PKCδに対して強く標識された．\nAD海馬の残存ニューロンは高齢健常者と比較してPKCδ弱陽性であり，多くの細胞内NFTはCA1領\n域および海馬台ではPKCδ強陽性であった．AD海馬を免疫電子顕微鏡法で観察したところ，PKCδが\nNFTのpaired helical filaments（PHF），核，小胞，リソソームに局在していることが示された．免疫二重\n染色法では，PKCδがタウ病理に関与するGSK3βと広範囲に共局在していることが明らかとなった．こ\nれらの結果は，AD脳において，PKCδは細胞内NFTのPHFに局在し，タウ病理学において重要な役割\nを果たしていることを示唆している．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"item_10002_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"2758-1780","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"園田, 悠馬","creatorNameLang":"ja"},{"creatorName":"SONODA, Yuma","creatorNameLang":"en"}],"familyNames":[{"familyName":"園田","familyNameLang":"ja"},{"familyName":"SONODA","familyNameLang":"en"}],"givenNames":[{"givenName":"悠馬","givenNameLang":"ja"},{"givenName":"Yuma","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠山, 育夫","creatorNameLang":"ja"},{"creatorName":"TOOYAMA, Ikuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"遠山","familyNameLang":"ja"},{"familyName":"TOOYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"育夫","givenNameLang":"ja"},{"givenName":"Ikuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"秋山, 治彦","creatorNameLang":"ja"},{"creatorName":"AKIYAMA, Haruhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"秋山","familyNameLang":"ja"},{"familyName":"AKIYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"治彦","givenNameLang":"ja"},{"givenName":"Haruhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"29","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川又, 敏男","creatorNameLang":"ja"},{"creatorName":"KAWAMATA, Toshio","creatorNameLang":"en"}],"familyNames":[{"familyName":"川又","familyNameLang":"ja"},{"familyName":"KAWAMATA","familyNameLang":"en"}],"givenNames":[{"givenName":"敏男","givenNameLang":"ja"},{"givenName":"Toshio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"11","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-04"}],"fileDate":[{"fileDateType":"Available","fileDateValue":"2025-06-04"}],"filename":"4.園田：Protein kinase C delta accumulates in neurofibrillary….pdf","filesize":[{"value":"11.8 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://bpur.repo.nii.ac.jp/record/2000061/files/4.園田：Protein kinase C delta accumulates in neurofibrillary….pdf"},"version_id":"4d1516eb-6efd-4f2a-b728-ff29690da15f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"protein kinase C delta","subitem_subject_scheme":"Other"},{"subitem_subject":"Alzheimer’s disease","subitem_subject_scheme":"Other"},{"subitem_subject":"neurofibrillary tangle","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"human brain","subitem_subject_scheme":"Other"},{"subitem_subject":"アルツハイマー型認知症","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"脳","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protein kinase C delta accumulates in neurofibrillary tangles in  Alzheimer’s disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protein kinase C delta accumulates in neurofibrillary tangles in  Alzheimer’s disease","subitem_title_language":"en"},{"subitem_title":"PKCδはアルツハイマー型認知症のタウタングルに蓄積する","subitem_title_language":"ja"}]},"item_type_id":"10002","owner":"7","path":["1721794263913"],"pubdate":{"attribute_name":"公開日","attribute_value":"2025-06-04"},"publish_date":"2025-06-04","publish_status":"0","recid":"2000061","relation_version_is_last":true,"title":["Protein kinase C delta accumulates in neurofibrillary tangles in  Alzheimer’s disease"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-06-04T07:35:57.275694+00:00"}