{"created":"2025-06-04T07:19:19.416060+00:00","id":2000062,"links":{},"metadata":{"_buckets":{"deposit":"4f85380c-94b0-45d3-9ae9-35e991d150cd"},"_deposit":{"created_by":7,"id":"2000062","owner":"7","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2000062"},"status":"published"},"_oai":{"id":"oai:bpur.repo.nii.ac.jp:02000062","sets":["1721794136137:1721794263913"]},"author_link":["30","31","32","16"],"item_10002_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicNumberOfPages":"9","bibliographicPageEnd":"49","bibliographicPageStart":"41","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"びわこ健康科学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Biwako Journal of Rehabilitation","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"成体海馬におけるニューロン新生を促進する最も重要な要因は身体活動である．消費エネルギー量は身\n体活動量の基本尺度であるが，消費エネルギー量を用いてニューロン新生を解析した研究は見当たらな\nい．そこで本研究では，成体マウスの飼育ケージに50 cm長の角度付きトンネルチューブを設置し，ト\nンネル角度を変化させることで，登坂による消費エネルギー量と海馬ニューロン新生との関係を解析し\nた．トンネル先端にはチミジンアナログのBrdUを含む給水瓶を設置し，2週間の飼育期間後，新生細\n胞を組織化学的に検出した．どのトンネル角度の場合でも，走歩距離（トンネル通過回数）・飲水量（BrdU\n摂取量）ともに有意差はなかった．2週間の飼育期間中に新生した細胞数を，BrdUを指標に解析したと\nころ，トンネル角度が大きくなるほど，BrdU陽性ニューロン数が有意に多かった．また標識された\nBrdU 摂取細胞はニューロン前駆細胞に分化していることも確認した．トンネル長は一定であるため，\nトンネル角度増加に比例して登坂による消費エネルギーも増大する．本研究から，海馬ニューロン新生\nには，消費エネルギーが重要な因子であることが明らかになった．すなわち，消費エネルギーの大きい\n運動療法が，おそらくはmyokine等の因子を介して脳の機能維持に働く可能性を示唆している．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"item_10002_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"2758-1780","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"紅林, 秀治","creatorNameLang":"ja"},{"creatorName":"KUREBAYASHI, Shuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"紅林","familyNameLang":"ja"},{"familyName":"KUREBAYASHI","familyNameLang":"en"}],"givenNames":[{"givenName":"秀治","givenNameLang":"ja"},{"givenName":"Shuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 太郎","creatorNameLang":"ja"},{"creatorName":"KOIKE, Taro","creatorNameLang":"en"}],"familyNames":[{"familyName":"小池","familyNameLang":"ja"},{"familyName":"KOIKE","familyNameLang":"en"}],"givenNames":[{"givenName":"太郎","givenNameLang":"ja"},{"givenName":"Taro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"31","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 徹自","creatorNameLang":"ja"},{"creatorName":"MORI, Tetsuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"森","familyNameLang":"ja"},{"familyName":"MORI","familyNameLang":"en"}],"givenNames":[{"givenName":"徹自","givenNameLang":"ja"},{"givenName":"Tetsuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"32","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 久夫","creatorNameLang":"ja"},{"creatorName":"YAMADA, Hisao","creatorNameLang":"en"}],"familyNames":[{"familyName":"山田","familyNameLang":"ja"},{"familyName":"YAMADA","familyNameLang":"en"}],"givenNames":[{"givenName":"久夫","givenNameLang":"ja"},{"givenName":"Hisao","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-04"}],"fileDate":[{"fileDateType":"Available","fileDateValue":"2025-06-04"}],"filename":"5.紅林：Amount of energy consumption during physical activity….pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://bpur.repo.nii.ac.jp/record/2000062/files/5.紅林：Amount of energy consumption during physical activity….pdf"},"version_id":"771af060-6e24-4548-be61-e43742ebd6bf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adult neurogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"hippocampus","subitem_subject_scheme":"Other"},{"subitem_subject":"physical activity","subitem_subject_scheme":"Other"},{"subitem_subject":"energy consumption","subitem_subject_scheme":"Other"},{"subitem_subject":"histochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"成体海馬","subitem_subject_scheme":"Other"},{"subitem_subject":"身体活動","subitem_subject_scheme":"Other"},{"subitem_subject":"エネルギー量","subitem_subject_scheme":"Other"},{"subitem_subject":"組織化学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Amount of energy consumption during physical activity is a key  element in the analysis of neurogenesis in the adult mouse  hippocampus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Amount of energy consumption during physical activity is a key  element in the analysis of neurogenesis in the adult mouse  hippocampus","subitem_title_language":"en"},{"subitem_title":"運動時の消費エネルギー量は  成体海馬ニューロン新生の鍵因子である","subitem_title_language":"ja"}]},"item_type_id":"10002","owner":"7","path":["1721794263913"],"pubdate":{"attribute_name":"公開日","attribute_value":"2025-06-04"},"publish_date":"2025-06-04","publish_status":"0","recid":"2000062","relation_version_is_last":true,"title":["Amount of energy consumption during physical activity is a key  element in the analysis of neurogenesis in the adult mouse  hippocampus"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-06-04T07:35:57.486327+00:00"}