{"created":"2025-06-09T02:13:10.328030+00:00","id":2000069,"links":{},"metadata":{"_buckets":{"deposit":"97e386aa-0eb2-42a5-b83a-f8d7a93c68c1"},"_deposit":{"created_by":7,"id":"2000069","owner":"7","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2000069"},"status":"published"},"_oai":{"id":"oai:bpur.repo.nii.ac.jp:02000069","sets":["1721794136137:1721794267443"]},"author_link":["10","11"],"item_10002_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicNumberOfPages":"7","bibliographicPageEnd":"16","bibliographicPageStart":"10","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"びわこ健康科学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Biwako Journal of Rehabilitation","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"スフィンゴ脂質の生合成の第1段階の重要な酵素であるセリン・パルミトイル転移酵素のサブユニット（SPT2）のヒト脳局在について，健常高齢者とアルツハイマー型認知症（AD）患者剖検例を用いて免疫組織化学染色にて定性評価した．健常コントロール脳では，SPT2はニューロンの細胞質および核に局在していた．AD脳では，SPT2はニューロピル（ニューロン間網状組織部），老人斑の変性神経突起，細胞内神経原線維変化（iNFT）などの特徴的病理像の部位へと主な局在が変化していた．二重免疫蛍光染色によって，NFTにおいてSPT2とタウタンパク質（HT-7）の共存が示された．さらに，反応性アストロサイトにおいてSPT2とグリア線維性酸性蛋白，ならびに軸索においてSPT2とリン酸化ニューロフィラメントタンパク質の共存性が示された．本研究結果は，AD患者のNFT形成などの疾患特異的病理変化におけるSPT2の関与を示唆している．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"item_10002_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"2758-1780","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"園田, 悠馬","creatorNameLang":"ja"},{"creatorName":"SONODA, Yuma","creatorNameLang":"en"}],"familyNames":[{"familyName":"園田","familyNameLang":"ja"},{"familyName":"SONODA","familyNameLang":"en"}],"givenNames":[{"givenName":"悠馬","givenNameLang":"ja"},{"givenName":"Yuma","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川又, 敏男","creatorNameLang":"ja"},{"creatorName":"KAWAMATA, Toshio","creatorNameLang":"en"}],"familyNames":[{"familyName":"川又","familyNameLang":"ja"},{"familyName":"KAWAMATA","familyNameLang":"en"}],"givenNames":[{"givenName":"敏男","givenNameLang":"ja"},{"givenName":"Toshio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"11","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-09"}],"fileDate":[{"fileDateType":"Available","fileDateValue":"2025-06-09"}],"filename":"2.園田：Localization of serine palmitoyltransferase in….pdf","filesize":[{"value":"3.7 MB"}],"format":"application/pdf","url":{"url":"https://bpur.repo.nii.ac.jp/record/2000069/files/2.園田：Localization of serine palmitoyltransferase in….pdf"},"version_id":"31e3984a-7494-4f85-a12c-b776f0927856"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"serine palmitoyltransferase","subitem_subject_scheme":"Other"},{"subitem_subject":"human brain","subitem_subject_scheme":"Other"},{"subitem_subject":"Alzheimer’s disease","subitem_subject_scheme":"Other"},{"subitem_subject":"neurofibrillary tangle","subitem_subject_scheme":"Other"},{"subitem_subject":"reactive astrocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Localization of serine palmitoyltransferase in human brain with  Alzheimer’s disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Localization of serine palmitoyltransferase in human brain with  Alzheimer’s disease","subitem_title_language":"en"},{"subitem_title":"アルツハイマー型認知症脳におけるSPT2の組織化学的局在","subitem_title_language":"ja"}]},"item_type_id":"10002","owner":"7","path":["1721794267443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2025-06-09"},"publish_date":"2025-06-09","publish_status":"0","recid":"2000069","relation_version_is_last":true,"title":["Localization of serine palmitoyltransferase in human brain with  Alzheimer’s disease"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-06-09T02:18:07.981094+00:00"}